In vitro Evidence for a Direct Anti-Fibrotic Role of the Immunosupressive Drug Mycophenolate Mofetil
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In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil.
The immunosuppressive drug mycophenolate mofetil (MMF) is used to prevent organ rejection after transplantation and has shown some efficacy to prevent the fibrotic complications that occur during autoimmune diseases such as systemic sclerosis or during graft-versus-host disease (GVHD). We tested the hypothesis that MMF may exert direct effects on fibroblast extracellular matrix remodeling. Incu...
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